Senile cataract-related accumulation of Lewis(x) glycolipid in human lens.
نویسندگان
چکیده
منابع مشابه
Morphological and morphometrical study of human lens in senile cataract.
Histological changes were studied in 34 senile cataractous lenses removed surgically from patients aged 50 to 78 years. Sixty-eight percent had nuclear sclerosis, 44% swollen cells and morgagnian globular changes, 23% calcium deposition, 15% migration of epithelial cells beneath posterior capsule and villous projection in posterior in 7%. Several cases had more than one histological abnormality...
متن کاملIncrease in lens gangliosides due to aging and cataract progression in human senile cataract.
Gangliosides were isolated from human senile cataractous lenses by solvent extraction, DEAE-Sephadex column chromatography, and thin-layer chromatography. The content and composition of gangliosides were examined in individual lens tissues. Three predominant gangliosides, GM3, GM1, and GD1a, were tentatively identified in comparison with authentic brain gangliosides, and several unidentified ga...
متن کاملHuman Senile Cataractous Lens Protease
A proteolytic enzyme was isolated from human senile cataractous lens by anion-exchange and gel-filtration chromatography. Sedimentation and zoneelectrophoretic experiments indicated a high degree of homogeneity for the enzyme. A molecular weight of 27000 was calculated from measurements of sedimentation velocity and diffusion coefficient. Chelating agents decreased activity which could be resto...
متن کاملThe thickness of the human lens cortex in the different types of senile cataract.
In every type of beginning senile cataract the cortex of the lens measured with the slit lamp appears thinner than the normal lens cortex in the same age group. The decreased rate of fiber formation and of proteosynthesis precedes the first appearance of lens opacities.
متن کاملEnzyme activities in human lens epithelium of age-related cataract.
PURPOSE To investigate associations between enzyme activity of glutathione reductase (GR) with and without added flavin adenine dinucleotide (FAD), glutathione peroxidase (GPX), and 6-phosphogluconic dehydrogenase (6PGDH) in the lens epithelium collected at surgery, and some nutritional and biochemical variables determined in the same individuals during the Italian-American Case-Control Study o...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1992
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)50449-5